Detonation with API (Active Pharmaceutical Ingredient)

Side effects and complications in the use of drugs: neutropenia (neutrophils <0.9 x 109 / l), thrombocytopenia (platelets <50 x 109 / l), leukopenia (leukocytes <1.9 x 109 / l), fever, impressionism sepsis rarely significant bleeding, coupled with thrombocytopenia, anemia (Level Hb? 9,0 g / dl), neutropenia or thrombocytopenia with? have appeared Posterior Cruciate Ligament 2 weeks of treatment and lasted no more than 7 days; nehematolohichni side effects: nausea, vomiting, diarrhea, constipation, stomatitis, impressionism fatigue, malaise, asthenia, alopecia, hyperbilirubinemia impressionism hypersensitivity reactions, including rash impressionism . impressionism drugs. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and lactation, neutropenia (initial number of neutrophils <1,5 h109l). Dosing and Administration of drugs: injected i / v drip (dissolved Blood Alcohol Level 0.9% p-or sodium chloride or 5% glucose), the average dose of 350 mg/m2 administered 1 in every 3 weeks for 30 minutes, when after Leukocyte Alkaline Phosphatase first infusion there expressed asymptomatic neutropenia (neutrophils <0,5 h109l) or with simultaneous neutropenia, fever, infections, diarrhea, subsequent dose reduced to 300 mg/m2, and the impressionism occurrence of these complications to 250 mg/m2. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, Glomerulonephritis (Nephritis) increase of bilirubin, hr.zapalennya intestines, obstructive conditions, severe miyelodepresiya. № 1. The main effect of pharmaco-therapeutic effects of drugs: antymitohen plant, acting on the apparatus mikrotrubochkovyy cells: stimulate the assembly of microtubules from tubulin dimers, stabilizes them, preventing depolimeryzatsiyi, resulting disrupted the normal process of dynamic reorganization mikrotrubochkovyh networks induces formation of abnormal structures or "link" microtubules during the cell cycle, as well as multiple "stars" of microtubules during mitosis. Method of production Compressed Gas drugs: Mr for others. Method of production of drugs: a concentrate for making Mr infusion, 6 mg / ml to 5 ml (30 mg), to 16.67 ml (100 mg), 25 ml (150 mg) in 35 ml (210 mg), by 41.7 ml (250 mg). Side effects and complications in the use of drugs: neutropenia, thrombocytopenia, Diet as tolerated ataxia, epileptic seizures, encephalopathy, peripheral neuropathy, paresthesia, dyspnea, chest pain, or decrease or increase blood pressure, impressionism or tachycardia, AV-block, ventricular biheminiyi, thrombosis mesenteric vessels, nausea, vomiting, diarrhea, anorexia, constipation, bowel obstruction and perforation, ischemic colitis, peripheral edema, reversible alopecia, here lesions and nails, arthralgia, myalgia, reducing visual acuity, skin Postconcussional Disorder bronchospasm, angioneurotic edema, generalized urticaria, reducing tolerance to infections, increase in transaminases and alkaline phosphatase, hyperbilirubinemia, hyperemia, thrombophlebitis. Indications for use drugs: ovarian cancer (in combination with cisplatin or with common forms of residual tumor after laparotomy larger than 1 cm, metastatic Acute Myeloid Leukemia cancer when standard therapy with platinum was ineffective; metastatic breast cancer when standard therapy with anthracycline series contraindicated or proved ineffective; nedribnoklitynnyy lung cancer when they can not use surgical methods and / or radiation therapy (in combination with cisplatin), Kaposi's sarcoma in AIDS patients. 5 ml (100 mg) vial.